Lebenslauf und Publikationen

Scientific CV

06/2020 - now	Ph.D. student Institute of Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute for Technology (KIT)
11/2019 - 04/2020	Internship in Technical Development Moderna Inc, Cambridge, MA, USA Model-based development of chromatography processes for plasmid DNA purification
03/2019 - 09/2019	Master’s Thesis GoSilico GmbH, Karlsruhe, Germany Experimental and theoretical analysis of cross-flow ultrafiltration and diafiltration processes of highly concentrated protein solutions
09/2018 - 02/2019	Research project Institute of Bioengineering & Biosystems, Insituto Superior Técnico, Lisbon, Portugal Development of a multimodal chromatography process for the purification of recombinant Penicillin G Acylase using microfluidics screening techniques
02/2018-08/2018	Research assistant Institute of Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute for Technology (KIT) Monitoring of a continuous precipitation and resolubilization process using FTIR spectroscopy
04/2017 - 04/2020	M.Sc. Biological Engineering Karlsruhe Institute for Technology (KIT)
06/2017 - 11/2017	Research Assistant Institute of Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute for Technology (KIT) Programming of a machine to machine communication protocol for an ÄKTA chromatography system
09/2017 - 04/2017	Internship in CMC, Biopharm Purification Novo Nordisk A/S, Gentofte, Denmark High-throughput development of an affinity chromatography step for a monoclonal antibody
06/2016 - 09/2017	Bachelor’s Thesis Institute of Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute for Technology (KIT) Spectral Deconvolution of protein chromatograms using calibration-free methods
10/2013 - 09/2017	B.Sc. Biological Engineering Institute of Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute for Technology (KIT)

Research Projects

Implementation of artificial intelligence and machine learning methods for PAT and process control.

Publications

Paper

Rüdt, M., Andris, S., Schiemer, R., & Hubbuch, J., Factorization of preparative protein chromatograms with hard-constraint multivariate curve resolution and second-derivative pretreatment, Journal of Chromatography A, 1585. (2019) 152-160, https://doi.org/10.1016/j.chroma.2018.11.065.