CV and Publications

Scientific CV

06/2021 – now	PhD student Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
04/2018 – 03/2021	M.Sc. Bioengineering Master’s thesis: Process monitoring of virus-like particle disassembly by cross-flow filtration using spectroscopic methods Karlsruhe Institute of Technology (KIT)
12/2020 – 02/2021	Student research assistant Experiments on on-line monitoring of virus-like particle disassembly Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
09/2019 – 02/2020	Internship Mechanistic modeling of cation-exchange chromatography (CEX) Novartis, Drug Product Process Development, Basel (Schweiz)
09/2018 – 08/2019	Student research assistant Upstream processing of virus-like particles in E.coli and downstream process development Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
11/2017 – 04/2018	Internship Roche Diagnostics GmbH, Sterile Drug Product Manufacturing, Mannheim
10/2014 – 10/2017	B.Sc. Bioengineering Bachelor’s thesis: From µL-screening to technical crystallization of beta-Lactoglobulin und BSA Karlsruhe Institute of Technology (KIT)

Research Projects

Process and analytical development and PAT implementation for carrier systems with nucleic acid cargo.

Teaching

Supervision of laboratory training Biotechnology (Section: Purification).

Publications

Papers

N. Hillebrandt, P. Vormittag, A. Dietrich and J. Hubbuch, Process Monitoring Framework for Cross-flow Diafiltration-based Virus-like Particle Disassembly: Tracing Product Properties and Filtration Performance, Biotechnology and Bioengineering (2022) 1–17, https://doi.org/10.1002/bit.28063.
N. Hillebrandt, P. Vormittag, A. Dietrich, C.H. Wegner and J. Hubbuch, Process development for cross-flow diafiltration-based VLP disassembly: A novel high-throughput screening approach, Biotechnology and Bioengineering 118 (2021) 3926–3940, https://doi.org/10.1002/bit.27868.
N. Hillebrandt, P. Vormittag, N. Bluthardt, A. Dietrich and J. Hubbuch, Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration, Front. Bioeng. Biotechnol. 8 (2020), https://doi.org/10.3389/fbioe.2020.00489.