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Frank Haemmerling

Dr.-Ing. Frank Hämmerling

PhD student
room: R. 207
phone: +49 721 608 47529
fax: +49 721 608 46240
frank haemmerlingPcm9∂kit edu

Fritz-Haber-Weg 2
Gebäude 30.44
76131 Karlsruhe



CV and Publications

Scientific CV

07/2012 - now PhD student
  Institute of Process Engineering in Life Sciences, Biomolecular Separation Engineering, KIT
10/2011 - 03/2012 Internship at BioMarin Pharmaceutical Inc., Novato, USA
Implementation of automated High-Throughput Process Development (HTPD) for the purification of pharmaceutical proteins
06/2011 - 08/2011 Scientific member
Institute of Process Engineering in Life Sciences, Biomolecular Separation Engineering, KIT
11/2010 - 05/2011 Diploma Thesis: „Development of process steps for the purification of egg white avidin using robot-based high-throughput screening (HTS)“
Institute of Process Engineering in Life Sciences, Biomolecular Separation Engineering, KIT
10/2009 - 03/2010 Student research project: „Establishment of self-interaction chromatography for determination of osmotic second virial coefficient for protein crystallization“
Institute of Engineering in Life Sciences, Biomolecular Separation Engineering, KIT
10/2008 - 03/2009 Internship at Wacker Chemie AG, Burghausen, Germany
Establishment and initial start-up of an online measurement of viscosity in the production of silicone oil emulsions.
10/2005 - 05/2011 Studies of Life Science Engineering



 

Research Projects

Characterization of aggregation behavior and stability of influenza viruses.

Quantitative Structure-Activity Relationship (QSAR) based process development for the purification of biomolecules.



 

Publications

Paper

F. Hämmerling, O. Lorenz-Cristea, P. Baumann, J. Hubbuch
Strategy for assessment of the colloidal and biological stability of H1N1 influenza A viruses, International Journal of Pharmaceutics 517 (2017), 87-97. http://dx.doi.org/10.1016/j.ijpharm.2016.11.058.

F. Hämmerling, C. Ladd Effio, S. Andris, J. Kittelmann, J. Hubbuch
Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure-activity relationship models, Journal of Biotechnology 241 (2017), 87-97. http://dx.doi.org/10.1016/j.jbiotec.2016.11.014.

K. C. Bauer, F. Hämmerling, J. Kittelmann, C. Dürr, F. Görlich, J. Hubbuch
Influence of structure properties on protein-protein interactions - QSAR modeling of changes in diffusion coefficients, Biotechnology and Bioengineering, accepted manuscript. http://onlinelibrary.wiley.com/doi/10.1002/bit.26078/abstract.

J. Kittelmann, F. Hämmerling, M. Ebeler, J. Hubbuch
Light extinction and scattering by agarose based resin beads and applications in high-throughput screening, Journal of Chromatography A 1397 (2015), 52–58. http://dx.doi.org/10.1016/j.chroma.2015.04.013.

P. Diederich, S. Amrhein, F. Hämmerling, J. Hubbuch
Evaluation of PEG/phosphate aqueous two-phase systems for the purification of the chicken egg white protein avidin by using high-throughput techniques, Chemical Engineering Science 104 (2013), 945-956. http://dx.doi.org/10.1016/j.ces.2013.10.008.
 

Poster

F. Hämmerling, O. Lorenz-Cristea, J. Hubbuch
Aggregation of H1N1 influenza virus during manufacturing and formulation, 36th International Symposium on the Separation of Proteins, Peptides and Polynucleotides (ISPPP), November 6-9, 2016, Salzburg, Austria.

F. Hämmerling, J. Kittelmann, T. Hahn, S. A. Oelmeier, J. Hubbuch
A QSAR model for prediction of protein adsorption in anion exchange chromatography and in silico simulation of chromatograms, 34th International Symposium on the Separation of Proteins, Peptides and Polynucleotides (ISPPP), November 5-7, 2014, Würzburg, Germany.

K. Tran, J. Maga, F. Haemmerling, B. Youn, S. Gu, D. Krawitz, and K. Antonsen
Strategy for Implementing Automated High Throughput Process Development for Purification of a Lysosomal Enzyme, 2nd International Conference on High-Throughput Process Development, June 4-7, 2012, Avignon, France.

P. Diederich, F. Hämmerling, J. Hubbuch
High Throughput Screening of Aqueous Two-Phase Systems for the Purification of Hen’s Egg White Protein Avidin, GVC/DECHEMA „Bioverfahrenstechnik an Grenzflächen”, May 30-June 1, 2011, Potsdam, Germany.