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Johannes Winderl

Dipl.-Wi.-Ing. Johannes Winderl

PhD student
room: R. 102
phone: +49 721 608 46227
fax: +49 721 608 46240
johannes winderlKar7∂kit edu

Fritz-Haber-Weg 7
Gebäude 30.91
76131 Karlsruhe



Lebenslauf und Publikationen

Scientific CV

10/2014 - now Research associate and PhD candidate at the Institute of Engineering in Life Sciences, Karlsruhe Institute for Technology
02/2014 - 08/2014 Co-op in the Purification Development department at Genentech Inc., South San Francisco, USA: Mechanistic modeling of ion exchange chromatography steps for process characterization and validation
10/2012 - 08/2013 Visiting Student Researcher in the Department of Neurology and Neurological Sciences, Steinman lab, Stanford University School of Medicine, USA: The role of aB-crystallin in oligodendrocytes
08/2012 - 10/2012 Intern at Glatt Ingenieurtechnik GmbH, Weimar, Germany: Development of a GMP framework for continuous fluid bed dryers
04/2012 – 06/2012 Intern at the Institute for Virology and Immunobiology, Berberich lab, University of Würzburg: Research on terminal B cell differentiation
02/2012 – 04/2012 Graduate research project at the Institute of Toxicology and Genetics, Grabher lab, Karlsruhe Institute of Technology: In situ hybridization analysis of gene expression of putative target genes of anti-inflammatory drugs upon chemically induced inflammation in zebrafish
07/2011 - 09/2013 Graduate studies, Biochemical and Business Engineering, Karlsruhe Institute of Technology
02/2011 – 06/2011 Bachelor thesis in the Department of Physiological Chemistry, Gaubatz lab, University of Würzburg: Analysis of GAS2L3 phosphorylation sites and their influence on GAS2L3 protein stability and cellular localization
10/2008 - 07/2011 Undergraduate Studies, Biomedicine, University of Würzburg
10/2005 - 09/2008 Undergraduate Studies, Business Engineering, Karlsruhe Institute of Technology



 

Research Projects

Characterization and modeling of novel chromatography media and single use systems



 

Publications

Paper

O. Ötes, J. Winderl, J. Hubbuch, H. Flato, F. Capito, Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a hybrid process vs. a conventional batch process, J. Biotechnol. 259 (2017) 213-220, https://doi.org/10.1016/j.jbiotec.2017.07.001.

J. Winderl, T. Hahn, J. Hubbuch, A mechanistic model of ion-exchange chromatography on polymer fiber stationary phases, J. Chromatogr. A 1475 (2016) 18-30, http://dx.doi.org/10.1016/j.chroma.2016.10.057.

R. Schubert, Y. Hu, G. Kumar, S. Szeto, P. Abraham, J. Winderl, J. Guthridge, G. Pardo, J. Dunn, L. Steinman, R. Axtell, IFN-β treatment requires B cells for efficacy in neuroautoimmunity, J. Immunol. 194 (2015) 2110-6, http://dx.doi.org/10.4049/jimmunol.1402029.

H. Kuipers, J. Yoon, J. Winderl, J. van Horssen, M. Han, T. Palmer, L. Steinman, Differential phosphorylation of alpha B-crystallin in astrocytes and oligodendrocytes suggests a diversity in its biological function, J. Neuroimmunol. 275 (2014) 157-158, http://dx.doi.org/10.1016/j.jneuroim.2014.08.423.
 

Talks

J. Winderl, T. Hahn, J. Hubbuch, Mechanistic modeling of fiber-based ion exchange adsorbents, 13th International PhD Seminar on Chromatographic Separation Science (SoCSS 2017), Annweiler am Trifels, Germany, February 26-28, 2017.

H. Kuipers, J. Yoon, J. Winderl, J. van Horssen, M. Han, T. Palmer, L. Steinman, Differential phosphorylation of alpha B-crystallin in astrocytes and oligodendrocytes suggests a diversity in its biological function, 12th International Congress of Neuroimmunology (ISNI), Mainz, Germany, November 9-13, 2014.
 

Poster

J. Winderl, E. Neumann, J. Hubbuch, Exploration of Fiber-based Cation Exchange Adsorbents for the Removal of Monoclonal Antibody Aggregates, 30th International Symposium on Preparative and Process Chromatography, Philadelphia, USA, July 16-19, 2017.

J. Winderl, T. Hahn, J. Hubbuch, Mechanistic modeling of fiber-based adsorbents for ion exchange chromatography, Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany, May 22-24, 2017.

C. Williams, J. Winderl, T. Hahn, Mechanistic Modeling of a Cation Exchange Chromatography Step, High-Throughput Process Development 2014 (HTPD), Siena, Italy, October 6-9, 2014.