MAB -  Biomolecular Separation Engineering
Adrian Sanden

M.Sc. Adrian Sanden

  • Fritz-Haber-Weg 2
    Gebäude 30.44
    76131 Karlsruhe

CV and Publications

Academic CV

08/2016 - present PhD student at Karlsruhe Institute of Technology, Biomolecular Separation Engineering
10/2013 - 05/2016 Master of Science in Bioengineering at Karlsruhe Institute of Technology
05/2014 - 12/2015 Scientific Assistant at the Institute for Technical Biology
11/2013 - 03/2014 Internship: Student Scientist at CSL Behring in Melbourne, Department for Research and Development Albumin & IgG
10/2010 - 10/2013 Bachelor of Science in Bioengineering at Karlsruhe Institute of Technology

Area of research

Model based process development for biopharmaceuticals such as monoclonal antibodies and other proteins. Combination of multiple modelling techniques for the prediction of process conditions.

Publications

Articles

Adrian Sanden, Sandra Haas, Jürgen Hubbuch, Modifying an ÄKTApurifier System for the automated acquisition of samples for kinetic modelling of batch reactions, SLAS Technology, https://journals.sagepub.com/doi/10.1177/2472630319891976.

Adrian Sanden, Susanna Suhm, Matthias Rüdt, Jürgen Hubbuch, Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography, Journal of Chromatography A, Volume 1608, 20 Dezember 2019, Article 460410 https://www.sciencedirect.com/science/article/pii/S0021967319307940.

Steffen Großhans, Matthias Rüdt, Adrian Sanden, Nina Brestrich, Josefine Morgenstern, Stefan Heissler, Jürgen Hubbuch, In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography, Journal of Chromatography A, Volume 1547, 27 April 2018, Pages 37-44, https://www.sciencedirect.com/science/article/pii/S0021967318302772.

N. Brestrich, A. Sanden, A. Kraft, K. McCann, J. Bertolini, J. Hubbuch, Advances in inline quantification of co-eluting proteins in chromatography: Process-data-based model calibration and application towards real-life separation issues, Biotechnology and Bioengineering 2015, Volume112, Issue7, July 2015, Pages 1406-1416, http://onlinelibrary.wiley.com/doi/10.1002/bit.25546/abstract.

Presentations

Sanden A, Suhm S, Hubbuch J, In-line Fourier-Transform Infrared Spectroscopy as a PAT tool to monitor the integrated on-column PEGylation and purification of a Protein, ACS National Meeting and Exposition, Orlando, April 2019

Sanden A, Großhans S, Rüdt M, Brestrich N, Morgenstern J, Heissler S, Hubbuch J, Process Analysis for Preparative Protein Chromatography Using In-Line Attenuated Total Reflection Fourier Transform Infrared Spectroscopy, SPICA, Darmstadt, October 2018.

Steffen Großhans, Matthias Rüdt, Adrian Sanden, Nina Brestrich, Josefine Morgenstern, Stefan Heissler, Jürgen Hubbuch, In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography, ACS National Meeting and Exposition in New Orleans, March 2018 and ACS Best of BIOT Webinar, October 2018.

Sanden A, Großhans S, Rüdt M, Brestrich N, Morgenstern J, Heissler S, Hubbuch J, In-line FTIR als vielseitige Prozessanalysetechnologie bei Präperativer Chromatographie, Bruker Anwender-treffen, Ettlingen, Deutschland, 7th November 2017.

Poster

Steffen Großhans, Matthias Rüdt, Adrian Sanden, Nina Brestrich, Josefine Morgenstern, Stefan Heissler, Jürgen Hubbuch, In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography, HIC-DSP, Interlaken, February 2019

Adrian Sanden, Nina Brestrich, Steffen Großhans, Josefine Morgenstern, Matthias Rüdt, Stefan Heissler, Jürgen Hubbuch, In-line FT-IR as a versatile PAT tool for downstream processing of proteins, Dechema Himmelfahrtstagung, Neu-Ulm, May 2017

Preise

Best of BIOT award at the ACS National Meeting 2018

Lebenslauf und Publikationen

Akademischer CV

08/2016 - jetzt Doktorand am Institut für Bio- und Lebensmitteltechnik, Karlsruher Institut für Technologie (KIT)
10/2013 - 05/2016 Studium des Bioingenieurwesens, Master of Science, Karlsruher Institut für Technologie
05/2014 - 12/2015 Wissenschaftliche Hilfskraft: Karlsruher Institut für Technologie, Institut für Technische Biologie
11/2013 - 03/2014 Praktikum: Student Scientist bei CSL Behring in Melbourne, Department for Research and Development Albumin & IgG
10/2010 - 10/2013 Studium des Bioingenieurwesens, Bachelor of Science, Karlsruher Institut für Technologie



 

Forschungsbereich

Modellbasierte Prozessentwicklung für biopharmazeutische Wirkstoffe wie monoklonale Antikörper und andere Proteine. Kombination von verschiedenen Modellierungstechniken zur Vorhersage von Prozessbedingungen.




Publikationen

Publikationen

Artikel

Adrian Sanden, Sandra Haas, Jürgen Hubbuch, Modifying an ÄKTApurifier System for the automated acquisition of samples for kinetic modelling of batch reactions, SLAS Technology, https://journals.sagepub.com/doi/10.1177/2472630319891976.

Adrian Sanden, Susanna Suhm, Matthias Rüdt, Jürgen Hubbuch, Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography, Journal of Chromatography A, Volume 1608, 20 Dezember 2019, Article 460410 https://www.sciencedirect.com/science/article/pii/S0021967319307940.

Steffen Großhans, Matthias Rüdt, Adrian Sanden, Nina Brestrich, Josefine Morgenstern, Stefan Heissler, Jürgen Hubbuch, In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography, Journal of Chromatography A, Volume 1547, 27 April 2018, Pages 37-44, https://www.sciencedirect.com/science/article/pii/S0021967318302772.

N. Brestrich, A. Sanden, A. Kraft, K. McCann, J. Bertolini, J. Hubbuch, Advances in inline quantification of co-eluting proteins in chromatography: Process-data-based model calibration and application towards real-life separation issues, Biotechnology and Bioengineering 2015, Volume112, Issue7, July 2015, Pages 1406-1416, http://onlinelibrary.wiley.com/doi/10.1002/bit.25546/abstract.


 

Vorträge

Sanden A, Suhm S, Hubbuch J, In-line Fourier-Transform Infrared Spectroscopy as a PAT tool to monitor the integrated on-column PEGylation and purification of a Protein, ACS National Meeting and Exposition, Orlando, April 2019

Sanden A, Großhans S, Rüdt M, Brestrich N, Morgenstern J, Heissler S, Hubbuch J, Process Analysis for Preparative Protein Chromatography Using In-Line Attenuated Total Reflection Fourier Transform Infrared Spectroscopy, SPICA, Darmstadt, October 2018.

Steffen Großhans, Matthias Rüdt, Adrian Sanden, Nina Brestrich, Josefine Morgenstern, Stefan Heissler, Jürgen Hubbuch, In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography, ACS National Meeting and Exposition in New Orleans, March 2018 und ACS Best of BIOT Webinar, Oktober 2018.

Sanden A, Großhans S, Rüdt M, Brestrich N, Morgenstern J, Heissler S, Hubbuch J, In-line FTIR als vielseitige Prozessanalysetechnologie bei Präperativer Chromatographie, Bruker Anwender-treffen, Ettlingen, Deutschland, 7. November 2017.
 

Poster

Steffen Großhans, Matthias Rüdt, Adrian Sanden, Nina Brestrich, Josefine Morgenstern, Stefan Heissler, Jürgen Hubbuch, In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography, HIC-DSP, Interlaken, Februar 2019

Adrian Sanden, Nina Brestrich, Steffen Großhans, Josefine Morgenstern, Matthias Rüdt, Stefan Heissler, Jürgen Hubbuch, In-line FT-IR as a versatile PAT tool for downstream processing of proteins, Dechema Himmelfahrtstagung, Neu-Ulm, May 2017
 

Preise

Best of BIOT award beim ACS National Meeting 2018.