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Matthias Rüdt

Dr.-Ing. Matthias Rüdt

Postdoc
room: R. 225
phone: +49 721 608 47534
fax: +49 721 608 46240
matthias ruedtMjm1∂kit edu

Fritz-Haber-Weg 2
Gebäude 30.44
76131 Karlsruhe



CV and Publications

Scientific CV

08/2018 - now Postdoc at the Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
01/2015 - 07/2018 PhD student at the Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
01/2014 - 10/2014 Scientist in Tech. Dev. in Downstream-Processing at Lek Pharmaceuticals d.d. (Sandoz), Slovenia
04/2013 - 12/2013 Internship on Model-based Chromatography Development in the Biologics Downstream-Processing Group, Novartis Pharma, Switzerland
03/2012 - 09/2012 Master thesis titled Studies on Multilayer Micropost Arrays in the Microsystems Group at Stanford University, California, USA
09/2011 - 02/2013 Master studies in biotechnology at the ETH Zürich, Switzerland
09/2010 - 08/2011 Bachelor studies in biotechnology at ETH Zürich, Switzerland
09/2008 - 08/2010 Basic studies in Chemistry at ETH Zürich, Switzerland



 

Research Projects

Development and application Process Analytical Technology (PAT) to preparative protein purification.



 

Publications

Articles

Großhans S, Rüdt M, Sanden A, Brestrich N, Morgenstern J, Heissler S, Hubbuch J. In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography, J Chromatogr A 1547 (2018) 37–44, http://dx.doi.org/10.1016/j.chroma.2018.03.005.

Brestrich N, Rüdt M, Büchler D, Hubbuch J, Selective protein quantification for preparative chromatography using variable pathlength UV/Vis spectroscopy and partial least squares regression, Chem Eng Sci 176 (2018) 157–164,http://dx.doi.org/10.1016/j.ces.2017.10.030.

Rüdt M, Briskot T, Hubbuch J, Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology, J Chromatogr A 1490 (2017), 2–9, http://dx.doi.org/10.1016/j.chroma.2016.11.010

Rüdt M, Brestrich N, Rolinger L, Hubbuch J. Real-time monitoring and control of the load phase of a protein A capture step. Biotechnol Bioeng 2017; 114:368–73, http://dx.doi.org/10.1002/bit.26078.

M. Rüdt, F. Gillet, S. Heege, J. Hitzler, B. Kalbfuss, B. Guélat, Combined Yamamoto approach for simultaneous estimation of adsorption isotherm and kinetic parameters in ion-exchange chromatography, J Chromatogr A 1413 (2015) 68-76, http://dx.doi.org/10.1016/j.chroma.2015.08.025.
 

Presentations

Rüdt M, Brestrich N, Hubbuch J, Spectral deconvolution of chromatograms with PLS models and calibration-free methods, ACS Spring Meeting 2016, San Diego, USA, 14th March 2016.

Rüdt M, Brestrich N, Büchler D, Rolinger L, Sanden A, Hubbuch J, PAT for preparative chromatography of proteins: Real-time monitoring of a capture and polishing step, SPICA 2016, Wien, Österreich, 11th October 2016.

Wang G, Briskot T, Rüdt M, Hubbuch J, Simulated Periodic Counter-Current Chromatography (sPCCC) – a scale-down model for multicolumn continuous chromatography process development, SPICA 2016, Wien, Österreich, 12th October 2016.

Rüdt M, Brestrich N, Büchler D, Schiemer R, Hubbuch J, Analyzing Protein UV/Vis Chromatograms with PLS Models and Calibration-free Methods, Thermo Fisher Chromatographie An-wenderseminar, Pforzheim, Deutschland, 1st March 2017.

Rüdt M, Brestrich N, Büchler D, Rolinger L, Sanden A, Hubbuch J, Real-time monitoring of critical quality attributes and process parameters by spectroscopy during chromatographic capture and polishing steps, ACS Spring Meeting 2017, San Francisco, United States, 2nd April 2017.

Sanden A, Großhans S, Rüdt M, Brestrich N, Morgenstern J, Heissler S, Hubbuch J, In-line FTIR als vielseitige Prozessanalysetechnologie bei Präperativer Chromatographie, Bruker Anwender-treffen, Ettlingen, Deutschland, 7th November 2017.

Rolinger L, Brestrich N, Rüdt M, Hubbuch J, Real-time monitoring and control of the load phase of a protein A capture step, ACS Spring Meeting 2018, New Orleans, USA, 18th March 2018.

Sanden A, Großhans S, Rüdt M, Brestrich N, Morgenstern J, Heissler S, Hubbuch J, In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography, New Orleans, USA, 20th March 2018.

Rüdt M, Brestrich N, Rolinger L, Hubbuch J, Process Analytical Technology in DSP, Dublin, Irland, 27th March 2018.
 

Posters

N. Brestrich, M. Rüdt, L. Rolinger, J. Hubbuch, Application of PAT in chromatography: from capture to polishing, Recovery of Biological Products XVII, Bermuda, 20th June 2016.

M. Rüdt, N. Brestrich, J. Hubbuch, Spectral deconvolution of chromatograms without offline analytics, Integrated Continuous Bioprocessing (ICB) 2, Berkeley, Kalifornien, USA, 2nd November 2015.