CV and Publications

Scientific CV

01/2012 - now	PhD student at the Institute of Engineering in Life Sciences, Karlsruhe Institute of Technology
03/2011 - 10/2011	Master thesis “Overexpression of glyoxalase I and aldose-reductase in HAEC and characterisation of the methylglyoxal-induced modification of Hsp27“, Herz- und Diabeteszentrum NRW, Bad Oeynhausen
03/2011 - 10/2011	Research project “Expression and modification of Hsp27 in E.coli“, Herz- und Diabeteszentrum NRW, Bad Oeynhausen
09/2009 - 12/2011	Studies of “Molecular Biotechnology“ (M.Sc.), University Bielefeld
04/2009 - 08/2009	Bachelor thesis “Recombinant preparation of several variants of the human heat shock protein Hsp27 in E.coli“, Herz- und Diabeteszentrum NRW, Bad Oeynhausen
09/2006 - 08/2009	Studies of “Molecular Biotechnology“ (B.Sc.), University Bielefeld

Research Projects

Development of industrial chromatographic processes: Model derived high-throughput process development and development of high-throughput compatible analytics.

Publications

Paper

T. Hahn, P. Baumann, T. Huuk, V. Heuveline, J. Hubbuch, UV absorption-based inverse modeling of protein chromatography, Eng. Life Sci. (2015), http://dx.doi.org/10.1002/elsc.201400247.

T. Hahn, T. Huuk, V. Heuveline, J. Hubbuch, Simulating and Optimizing Preparative Protein Chromatography with ChromX, J. Chem. Educ. (2015), http://dx.doi.org/10.1021/ed500854a.

T. Hahn, T. Huuk, A, Osberghaus, K. Doninger, S. Nath, S. Hepbildikler, V. Heuveline, J. Hubbuch, Calibration-free inverse modeling of ion-exchange chromatography in industrial antibody purification, Eng. Life Sci. (2015), http://dx.doi.org/10.1002/elsc.201400248.

T. Huuk, T. Hahn, A. Osberghaus, J. Hubbuch, Model-based integrated optimization and evaluation of a multi-step ion exchange chromatography, Sep. Purif. Technol. 136 (2014) 207-222, http://dx.doi.org/10.1016/j.seppur.2014.09.012.

Talks

T. Huuk, T. Briskot, J. Hubbuch, A non-invasive method for adsorberquantification in high-throughput chromatography, 11th PhD Seminar on Chromatographic Separation Science, Sorpesee, Germany, February 15th.-17th. 2015.

T. Huuk, T. Hahn, A. Osberghaus, J. Griesbach, S. Hepbildikler, J. Hubbuch, Scalability of Mechanistic Models for Ion Exchange Chromatography, PREP 2014 – 27th International Symposium on Preparative and Process Chromatography, Boston, USA, July 20th.-23th. 2014.

T. Huuk, T. Hahn, A. Osberghaus, J. Hubbuch, Model-Based Integrated Optimization and Evaluation of a Multi-Step Ion Exchange Chromatography, 10th PhD Seminar on Chromatographic Separation Science, Egmond aan Zee, The Netherlands, February 23th.-25th. 2014.

T. Huuk, T. Hahn, A. Bogutzki, A. Osberghaus, J. Hubbuch, Model-based integrated optimization of multi-step ion exchange chromatography, 2nd European Congress of Applied Biotechnology (ECAB), The Hague, The Netherlands, April 15th. 2013.

T. Huuk, T. Hahn, A. Bogutzki, A. Osberghaus, J. Hubbuch, Optimization of multi-step ion exchange chromatography: A model-based approach, 9th PhD Seminar on Chromatographic Separation Science, Weggis, Switzerland, February 23th.-25th. 2013.

M. Degerman, B. Nilsson, A. Osberghaus, P. Baumann, T. Huuk, J. Hubbuch, M. Wiendahl, From data to knowledge: A model based approach to design high throughput experiments, Recovery of Biological Products XV, Stowe, USA, July 29th.- August 3rd. 2012.

Poster

T. Huuk, T. Hahn, J. Griesbach, S. Hepbildikler, J. Hubbuch, Scalability of Mechanistic Models for Ion Exchange Chromatography, Scale-up and scale-down of bioprocesses, Hamburg, Germany, Mai 11th.-13th. 2015.

T. Huuk, T. Hahn, A. Osberghaus, J. Hubbuch, Model-based concerted optimization of consecutive chromatogrphy steps, Integrated Continuous Biomanufacturing, Castelldefels, Spain, October 20th.-24th. 2013.