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Steffen Grosshans

MSc Steffen Großhans

PhD student
room: R. 201
phone: +49 721 608 46241
fax: +49 721 608 46240
steffen grosshansVin3∂kit edu

Fritz-Haber-Weg 2
Gebäude 30.44
76131 Karlsruhe



Lebenslauf und Publikationen

Scientific CV

05/2015 - now PhD student
Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
01/2015 - 04/2015 Scientific assistant: Correlation of Salt Impact on Protein Phase Behavior in Relation to HIC Elution and Thermal Stability
Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
05/2014 - 11/2014 Master thesis: Investigation of Salt Impact on Hydrophobicity and Solubility Behavior of Model Proteins in Dependence on pH
Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
10/2013 - 03/2014 Internship at Novo Nordisk A/S Gentofte/Denmark
Protein Phase Behavior with Focus on Isoelectic Precipitation
09/2012 - 12/2012 Student assistant: Upstream processing, optimisation of the fermentation
Institute of Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology (KIT)
04/2012 - 08/2012 Bachelor thesis: Screening the yeast cells Candida shehatae, Cryptococcus podzolicus and Scheffersomyces stipitis for the production of single cell oil
Institute of Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology (KIT)
10/2009 - 11/2014 Studies of Bioengineering at Karlsruhe Institute of Technology (KIT)



 

Research Projects

Protein phase behavior of biopharmaceutical proteins – Precipitation as unit operation in continuous downstream processing.



 

Publications

Paper

S. Großhans, G. Wang, C.Fischer, J. Hubbuch An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration, Journal of Chromatography A (2017). https://doi.org/10.1016/j.chroma.2017.12.013

K. Baumgartner, S. Großhans, J. Schütz, S. Suhm, J. Hubbuch Prediction of salt effects on protein phase behavior by HIC retention and thermal stability, Journal of pharmaceutical and biomedical analysis (2016), 128, 216-225, https://doi.org/10.1016/j.jpba.2016.04.040

I. Schulze, S. Hansen, S. Großhans, T. Rudszuck, K. Ochsenreither, C. Syldatk, A. Neumann, Characterization of newly isolated oleaginous yeasts-Cryptococcus podzolicus, Trichosporon porosum and Pichia segobiensis, AMB Express 4 (2014), 1-11, http://dx.doi.org/10.1186/s13568-014-0024-0
 

Talks

S. Großhans, G. Wang, P. Baumann, J. Hubbuch, Integrated precipitation and periodic counter-current chromatography process, ACS Spring Meeting 2017, San Francisco, California, 4th April 2017