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Amrhein

Dr.-Ing. Sven Amrhein

Postdoc
room: R. 106
phone: +49 721 608 47524
fax: +49 721 608 46240
sven amrheinJmg8∂kit edu

Engler-Bunte-Ring 3
Gebäude 40.12
76131 Karlsruhe



CV and Publications

Scientific CV

12/2012 - jetzt Ph.D. student at
Institute of Engineering in Life Sciences, Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
08/2014 - 11/2014 Research project at Genentech, South San Francisco
Automation in early stage formulation development
05/2012 - 04/2012 Diploma Thesis:
Molecular dynamics simulation of interactions between proteins and low-molecular substances,
Institute of Engineering in Life Sciences, Biomolecular Separation Engineering, KIT
11/2012 – 04/2012 Student assistant:
Investigation of the impact of errors on results obtained by high throughput screening for aqueous two phase systems,
Institute of Engineering in Life Sciences, Biomolecular Separation Engineering, KIT
04/2011 – 10/2011 Student research project:
Development and optimization of high throughput methods for purification of egg proteins using aqueous two phase systems,
Institute of Engineering in Life Sciences, Biomolecular Separation Engineering, KIT
10/2010 – 03/2011 Internship at Novo Nordisk A/S Gentofte/Denmark
Investigation of freeze/thaw processes and Statistical analysis of mAb purification data
04/2009 – 6/2010 Student assistant:
Research in solid/liquid hybrid separation processes and magnetic field enhanced cake filtration for bioseparation
Institute for Mechanical Process Engineering and Mechanics, Process Machines, KIT
10/2007 – 11/2012 Studies of Life Science Engineering, Karlsruhe Institute of Technology (KIT)


Research Projects

Molecular dynamic simulations for protein characterization:
The protein behavior in complex solutions such as aqueous two phase systems is investigated by means of the in silico approach of molecular dynamic simulations in combination of high throughput screenings.



Publications

Paper

S.Amrhein, M.-L.Schwab, M.Hoffmann, J.Hubbuch, Characterization of aqueous two phase systems by combining lab-on-a-chip technology with robotic liquid handling stations, J. Chromatogr. A, 1367C (2014) 68-77, http://dx.doi.org/10.1016/j.chroma.2014.09.042.

S.Amrhein, S.A.Oelmeier, F.Dismer, J.Hubbuch, Molecular Dynamics Simulations Approach for the Characterization of Peptides with Respect to Hydrophobicity, J. Phys. Chem. B, 118 (2014) 1707-1714, http://dx.doi.org/10.1021/jp407390f.

P.Diederich, S.Amrhein, F.Hämmerling, J.Hubbuch, Evaluation of PEG/phosphate aqueous two-phase systems for the purification of the chicken egg white protein avidin by using high-throughput techniques, Chem. Eng. Sci., 104 (2013) 945–956, http://dx.doi.org/10.1016/j.ces.2013.10.008.

Talks

S.Amrhein, K.Bauer, L.Galm, M.-T.Schermeyer, J.Hubbuch, Predictive Approaches for Protein Phase Behavior, Recovery of Biological Products Conference XVI, Rostock, Germany, July 27-31, 2014.

Poster

S.Amrhein, M.Wiendahl, O.E.Jensen, J.Hubbuch, Large Scale Freezing of mAb Solution GVC/DECHEMA -Conference, “Biopharmazeutische Produktion“, Freiburg, Germany, May 14-16, 2012.