MAB -  Biomolecular Separation Engineering
Sebastian Andris

Dipl.-Ing. Sebastian Andris

  • Fritz-Haber-Weg 2
    Gebäude 30.44
    76131 Karlsruhe

CV and Publications

Scientific CV

01/2016 - Now Ph.D. student at the Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
01/2015 - 7/2015 Internship at MedImmune, LLC, Gaithersburg, MD, USA
Protein conjugation and HPLC assay development
08/2014 - 12/2014 Research assistant:
Process Analytical Technology (PAT)
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, KIT
11/2013 - 06/2014 Diploma thesis:
Modeling of protein precipitation with polyethylene glycol (PEG) through quantitative structure-property relationships (QSPR)
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, KIT
04/2013 - 09/2013 Student assistant:
Microfluidics on Liquid Handling Stations (LHS)
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, KIT
06/2012 - 01/2013 Seminar thesis:
Establishment and validation of a microfluidic chip for high-throughput photometric analysis on a liquid handling robot
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, KIT
10/2011 - 03/2012 Internship at DOW Chemical Ibérica, S.L., Tarragona, Spain
Reverse Osmosis technology development for industrial water applications
10/2008 - 06/2014 Studies in Life Science Engineering, Karlsruhe Institute of Technology (KIT)

Research Projects

High Throughput approaches for multi-step protein conjugation processes; characterization and modeling of conjugation processes; investigation of pseudo-payloads for the development of conjugation processes.

Publications

Paper

Andris S, Rüdt M, Rogalla J, Wendeler M, Hubbuch J. Monitoring of antibody-drug conjugation reactions with UV/Vis spectroscopy. J Biotechnol 2018; 288:15–22. doi: 10.1016/J.JBIOTEC.2018.10.003.

Andris S, Wendeler M, Wang X, Hubbuch J. Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates. J Biotechnol 2018; 278:48–55. doi: 10.1016/j.jbiotec.2018.05.004.

Hämmerling F, Ladd Effio C, Andris S, Kittelmann J, Hubbuch J. Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure–activity relationship models. J Biotechnol 2017; 241. doi: 10.1016/j.jbiotec.2016.11.014.

Talks

Andris S, Wendeler M, Hubbuch J, Establishing a High-throughput Process Development Platform for an Antibody Conjugation Process, HTPD 2017, Toledo, Spain.

Poster

ESBES 2018, Lisbon, Portugal

ACS Spring Meeting 2018, New Orleans, LA, USA