Lebenslauf und Publikationen

Scientific CV

02/2018 - 02/2022	PhD student Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering at Karlsruhe Institute of Technology (KIT)
09/2017 - 01/2018	Research assistant Experiments on on-line monitoring of virus-like particle assembly Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering at Karlsruhe Institute of Technology (KIT)
10/2016 - 02/2017	Semester abroad Loughborough University, United Kingdom
06/2015 - 09/2016	Student assistant Development of a bioprinter (by modification of a 3D printer) and a corresponding software interface Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering at Karlsruhe Institute of Technology (KIT)
11/2014 - 03/2015	Internship Fermentation development and filtration optimization for DNA vaccine production Custom Development for Upstream Processing, Lonza AG, Visp, Switzerland
10/2014 - 08/2017	Studies of Bioengineering (M.Sc) Master thesis: Development and application of a PAT platform for monitoring the reassembly of virus-like particles by tangential flow filtration Karlsruhe Institute of Technology (KIT)
05/2012 - 10/2014	Student assistant Maintenance and supervision of bio reactors, performance of experiments and analysis Engler-Bunte-Institute, Chair of Water Chemistry and Water Technology at Karlsruhe Institute of Technology (KIT) & Water Technology Center Karlsruhe
10/2011 - 10/2014	Studies of Bioengineering (B.Sc) Bachelor thesis: Purification and characterization of a transaminase from Variovorax paradoxus Karlsruhe Institute of Technology (KIT)

Research Projects

Ultra- and diafiltration: process development and integration, on-line monitoring, high-throughput screenings, and modelling.

Teaching

Supervision of laboratory training Biotechnologie (Section: Purification) and Profilfach Biotechnologie.

Publications

Paper

N. Hillebrandt, P. Vormittag, A. Dietrich, C. H. Wegner, J. Hubbuch, Process development for cross-flow diafiltration-based VLP disassembly: A novel high-throughput screening approach, Biotechnol. Bioeng. 118 (2021), https://doi.org/10.1002/bit.27868.

N. Hillebrandt, P. Vormittag, N. Bluthardt, A. Dietrich, J. Hubbuch, Integrated Process for Capture and Purification of Virus-like Particles: Enhancing Process Performance by Cross-flow Filtration, Front. Bioeng. Biotechnol. 8 (2020), https://doi.org/10.3389/fbioe.2020.00489.

M. Rüdt, P. Vormittag, N. Hillebrandt, J. Hubbuch, Process monitoring of virus-like particle reassembly by diafiltration with UV/Vis spectroscopy and light scattering, Biotechnol. Bioeng. 116 (2019), https://doi.org/10.1002/bit.26935.

C. P. Radtke, N. Hillebrandt, J. Hubbuch, The Biomaker: an entry-level bioprinting device for biotechnological applications, J. Chem. Technol. Biotechnol. 93 (2018), http://dx.doi.org/10.1002/jctb.5429.

Talks

N. Hillebrandt, P. Vormittag, A. Dietrich, C. H. Wegner, T. Klamp, J. Hubbuch, Process development for cross-flow diafiltration-based VLP disassembly: A novel high-throughput screening approach, ACS Fall 2021 National Meeting, Atlanta, USA/virtual, August 25th 2021.

N. Hillebrandt, P. Vormittag, N. Bluthardt, A. Dietrich, T. Klamp, J. Hubbuch, Membrane-assisted precipitation and re-dissolution of virus-like particles: Approaches for an integrated capture step, ACS Spring 2020 National Meeting, virtual, March 22nd-26th 2020, https://doi.org/10.1021/scimeetings.0c03578.

Poster

N. Hillebrandt, P. Vormittag, N. Bluthardt, A. Dietrich, T. Klamp, J. Hubbuch, Integrated Process for Capture and Purification of Virus-like Particles: Enhancing Process Performance by Cross-flow Filtration, 13th European Symposium on Biochemical Engineering Sciences (ESBES) 2021, virtual, May 4th 2021.