M.Sc. Annabelle Dietrich
- PhD student
- room: R. 207
- phone: +49 721 608 46450
- fax: +49 721 608 46240
- annabelle dietrich ∂does-not-exist.kit edu
Fritz-Haber-Weg 2
Gebäude 30.44
76131 Karlsruhe
CV and Publications
Scientific CV
| 06/2021 – now | PhD student Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT) |
| 04/2018 – 03/2021 | M.Sc. Bioengineering Master’s thesis: Process monitoring of virus-like particle disassembly by cross-flow filtration using spectroscopic methods Karlsruhe Institute of Technology (KIT) |
| 12/2020 – 02/2021 | Student research assistant Experiments on on-line monitoring of virus-like particle disassembly Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT) |
| 09/2019 – 02/2020 | Internship Mechanistic modeling of cation-exchange chromatography (CEX) Novartis, Drug Product Process Development, Basel (Schweiz) |
| 09/2018 – 08/2019 | Student research assistant Upstream processing of virus-like particles in E.coli and downstream process development Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT) |
| 11/2017 – 04/2018 | Internship Roche Diagnostics GmbH, Sterile Drug Product Manufacturing, Mannheim |
| 10/2014 – 10/2017 | B.Sc. Bioengineering Bachelor’s thesis: From µL-screening to technical crystallization of beta-Lactoglobulin und BSA Karlsruhe Institute of Technology (KIT) |
Research Projects
Process development and PAT for non-viral vectors.
Teaching
Supervision of laboratory training Biotechnology (Section: Purification).
Publications
Paper
A. Dietrich, N. Beckert, J. Hubbuch. RP-CAD for Lipid Quantification: Systematic Method Development and Intensified LNP Process Characterization. Pharmaceuticals 17 (2024) 1217. https://doi.org/10.3390/ph17091217.
A. Dietrich, R. Schiemer, J. Kurmann, S. Zhang and J. Hubbuch, Raman-based PAT for VLP precipitation: Systematic data diversification and preprocessing pipeline identification, Front. Bioeng. Biotechnol. 12 (2024), https://doi.org/10.3389/fbioe.2024.1399938.
N. Hillebrandt, P. Vormittag, A. Dietrich and J. Hubbuch, Process Monitoring Framework for Cross-flow Diafiltration-based Virus-like Particle Disassembly: Tracing Product Properties and Filtration Performance, Biotechnology and Bioengineering (2022) 1–17, https://doi.org/10.1002/bit.28063.
N. Hillebrandt, P. Vormittag, A. Dietrich, C.H. Wegner and J. Hubbuch, Process development for cross-flow diafiltration-based VLP disassembly: A novel high-throughput screening approach, Biotechnology and Bioengineering 118 (2021) 3926–3940, https://doi.org/10.1002/bit.27868.
N. Hillebrandt, P. Vormittag, N. Bluthardt, A. Dietrich and J. Hubbuch, Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration, Front. Bioeng. Biotechnol. 8 (2020), https://doi.org/10.3389/fbioe.2020.00489.
Talks
A. Dietrich and J. Hubbuch, Novel Dual-stage Cross-flow Filtration-based Setup for Virus-like Particle Capture, 14th European Symposium on Biochemical Engineering Science ESBES 2024, Copenhagen, DK, October 2024.
A. Dietrich, N. Beckert and J. Hubbuch, Lipid Quantification by RP-CAD for Intensified LNP Process Characterization, 8th International Symposium on Phospholipids in Pharmaceutical Research, Heidelberg, DE, September 2024.
A. Dietrich, R. Schiemer and J. Hubbuch, Monitoring of HBcAg Virus-like Particle Precipitation using Raman Spectroscopy and Chemometrics, ACS Fall Meeting 2023, San Francisco, CA, US, August 2023.
Poster
A. Dietrich and J. Hubbuch, Novel Dual-stage Cross-flow Filtration-based Setup for Virus-like Particle Capture, 14th European Symposium on Biochemical Engineering Science ESBES 2024, Copenhagen, DK, October 2024.