An alternative approach for responding to pathogens by vaccination is the design of virus-like particles (VLPs). VLPs carry no replicative genetic information and can be produced in a variety of expression systems. Session 10 of the Virus-like Particle and Nano-Particle Vaccines meeting 2014 focused on new methods in vaccine technology to accelerate process development, manufacturing and quality control. The session presented new ways of quantifying and characterizing particle samples. In addition platform approaches for production and purification of VLP vaccines were highlighted.