Lebenslauf und Publikationen

Akademischer CV

02/2013 - jetzt	Doktorandin am Institut für Bio- und Lebensmitteltechnik, Karlsruher Institut für Technologie
06/2012 - 11/2012	Diplomarbeit: „Comparison of experimental and model-based parameter determination for sorption modeling in hydrophobic interaction chromatography“, Institut für Bio- und Lebensmitteltechnik, Karlsruher Institut für Technologie
05/2011 - 02/2012	Studienarbeit: „Bestimmung des optimalen Flüssigkeitsstandes im Sumpf bei der Flash-Kristallisation“, Institut für Thermische Verfahrenstechnik, Karlsruher Institut für Technologie
10/2010 - 03/2011	Industriepraktikum: „Optimization of sanitization conditions in protein A chromatography“, Genentech, Inc., San Francisco
04/2010 - 07/2010	Studentische Hilfskraft: Experimentelle Parameterbestimmung zur Chromatographiemodellierung, Institut für Bio- und Lebensmitteltechnik, Karlsruher Institut für Technologie
10/2008 - 03/2010	Studentische Hilfskraft: Betreuung von Mathematiktutorien, Institut für Algebra und Geometrie, Karlsruher Institut für Technologie
10/2007 - 11/2012	Studium des Bioingenieurwesens, Karlsruher Institut für Technologie

Forschungsbereich

Modellbasierte Online-Prozessanalyse für flüssigchromatographische Anwendungen

Publikationen

Artikel

N. Brestrich, T. Briskot, A. Osberghaus, J. Hubbuch, A tool for selective inline quantification of co-eluting proteins in chromatography using spectral analysis and partial least squares regression, Biotechnology and Bioengineering 111 (2014) 1365-1373, http://onlinelibrary.wiley.com/doi/10.1002/bit.25194/abstract.

N. Brestrich, A. Sanden, A. Kraft, K. McCann, J. Bertolini, J. Hubbuch, Advances in inline quantification of co-eluting proteins in chromatography: Process-data-based model calibration and application towards real-life separation issues, Biotechnology and Bioengineering 112 (2015) 1406-1416, http://onlinelibrary.wiley.com/doi/10.1002/bit.25546/abstract.

N. Brestrich, T. Hahn, J. Hubbuch, Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography, Journal of Chromatography A 1437 (2016) 158-167, http://www.sciencedirect.com/science/article/pii/S0021967316300978.

Vorträge

N. Brestrich, S. Hansen, A. Osberghaus, J. Hubbuch, A label-free methodology for selective inline quantification of co-eluting proteins in chromatography by means of spectral data, Integrated Continuous Biomanufacturing, Castelldefels, Spanien, 22. Oktober 2013.

N. Brestrich, T. Briskot, A. Osberghaus, J. Hubbuch, A tool for selective inline quantification of co-eluting proteins in chromatography using spectral data, 10th International PhD Seminar on Chromatographic Separation Science, Egmond aan Zee, Niederlande, 25. Februar 2014.

N. Brestrich, T. Briskot, A. Osberghaus, J. Hubbuch, Advances in model-based inline peak deconvolution: Process-data-based model calibration and real-time pooling decisions, 15th International Symposium on Preparative and Industrial Chromatography and Allied Techniques, Basel, Schweiz, 6. Oktober 2014.

N. Brestrich, A. Sanden, T. Briskot, J. Hubbuch, A PAT tool for chromatography enabling selective inline quantification and real-time pooling decisions, 11th International PhD Seminar on Chromatographic Separation Science, Sundern, Deutschland, 17. Februar 2015.

N. Brestrich, A. Sanden, T. Briskot, J. Hubbuch, A PAT tool for chromatography supporting batch and continuous processing, 249th ACS National Meeting and Exposition, Denver, USA, 25. März 2015.

N. Brestrich, A. Sanden, T. Briskot, J. Hubbuch, A PAT tool for chromatography supporting batch and continuous processing, Continuous Bioprocessing, Frankfurt, Deutschland, 27. April 2015.

N. Brestrich, A. Osberghaus, T. Hahn, J. Hubbuch, Model-based monitoring, control, and cause of error diagnostics of chromatography processes, 3rd European Congress of Applied Biotechnology, Nizza, Frankreich, 1. Oktober 2015.

N. Brestrich, T. Hahn, A. Sanden, T. Briskot, J. Hubbuch, PAT concepts for chromatography: Real-time monitoring, real-time control, and cause of error diagnostics, Integrated Continuous Biomanufacturing II, Berkeley, USA, 4. November 2015.

M. Rüdt, N. Brestrich, J. Hubbuch, Spectral deconvolution of chromatograms with PLS models and calibration-free methods, 251st ACS National Meeting and Exposition, San Diego, USA, 14. März 2015.

Poster

N. Brestrich, A. Sanden, K. McCann, J. Bertolini, J. Hubbuch, In-line detection of co-eluting proteins by spectral analysis during chromatographic purification of plasma protein: Application to PAT, Plasma Product Biotechnology Meeting, Chia Laguna, Italien, 13. Mai 2015.

M. Rüdt, N. Brestrich, J. Hubbuch, Spectral deconvolution of chromatograms without offline analytics, Integrated Continuous Biomanufacturing II, Berkeley, USA, 4. November 2015.

Preise

Emil Kirschbaum Preis 2014, Tag der Fakultät des Karlsruher Insituts für Technolgoie, Juni 2014.