Dr.-Ing. Frank Hämmerling
- PhD student
- room: R. 207
- phone: +49 721 608 47529
- fax: +49 721 608 46240
- frank haemmerling ∂ kit edu
Fritz-Haber-Weg 2
Gebäude 30.44
76131 Karlsruhe
CV and Publications
Scientific CV
07/2012 - now | PhD student |
Institute of Process Engineering in Life Sciences, Biomolecular Separation Engineering, KIT | |
10/2011 - 03/2012 | Internship at BioMarin Pharmaceutical Inc., Novato, USA Implementation of automated High-Throughput Process Development (HTPD) for the purification of pharmaceutical proteins |
06/2011 - 08/2011 | Scientific member Institute of Process Engineering in Life Sciences, Biomolecular Separation Engineering, KIT |
11/2010 - 05/2011 | Diploma Thesis: „Development of process steps for the purification of egg white avidin using robot-based high-throughput screening (HTS)“ Institute of Process Engineering in Life Sciences, Biomolecular Separation Engineering, KIT |
10/2009 - 03/2010 | Student research project: „Establishment of self-interaction chromatography for determination of osmotic second virial coefficient for protein crystallization“ Institute of Engineering in Life Sciences, Biomolecular Separation Engineering, KIT |
10/2008 - 03/2009 | Internship at Wacker Chemie AG, Burghausen, Germany Establishment and initial start-up of an online measurement of viscosity in the production of silicone oil emulsions. |
10/2005 - 05/2011 | Studies of Life Science Engineering |
Research Projects
Characterization of aggregation behavior and stability of influenza viruses.
Quantitative Structure-Activity Relationship (QSAR) based process development for the purification of biomolecules.
Publications
Paper
F. Hämmerling, O. Lorenz-Cristea, P. Baumann, J. Hubbuch
Strategy for assessment of the colloidal and biological stability of H1N1 influenza A viruses, International Journal of Pharmaceutics 517 (2017), 87-97. http://dx.doi.org/10.1016/j.ijpharm.2016.11.058.
F. Hämmerling, C. Ladd Effio, S. Andris, J. Kittelmann, J. Hubbuch
Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure-activity relationship models, Journal of Biotechnology 241 (2017), 87-97. http://dx.doi.org/10.1016/j.jbiotec.2016.11.014.
K. C. Bauer, F. Hämmerling, J. Kittelmann, C. Dürr, F. Görlich, J. Hubbuch
Influence of structure properties on protein-protein interactions - QSAR modeling of changes in diffusion coefficients, Biotechnology and Bioengineering, accepted manuscript. http://onlinelibrary.wiley.com/doi/10.1002/bit.26078/abstract.
J. Kittelmann, F. Hämmerling, M. Ebeler, J. Hubbuch
Light extinction and scattering by agarose based resin beads and applications in high-throughput screening, Journal of Chromatography A 1397 (2015), 52–58. http://dx.doi.org/10.1016/j.chroma.2015.04.013.
P. Diederich, S. Amrhein, F. Hämmerling, J. Hubbuch
Evaluation of PEG/phosphate aqueous two-phase systems for the purification of the chicken egg white protein avidin by using high-throughput techniques, Chemical Engineering Science 104 (2013), 945-956. http://dx.doi.org/10.1016/j.ces.2013.10.008.
Poster
F. Hämmerling, O. Lorenz-Cristea, J. Hubbuch
Aggregation of H1N1 influenza virus during manufacturing and formulation, 36th International Symposium on the Separation of Proteins, Peptides and Polynucleotides (ISPPP), November 6-9, 2016, Salzburg, Austria.
F. Hämmerling, J. Kittelmann, T. Hahn, S. A. Oelmeier, J. Hubbuch
A QSAR model for prediction of protein adsorption in anion exchange chromatography and in silico simulation of chromatograms, 34th International Symposium on the Separation of Proteins, Peptides and Polynucleotides (ISPPP), November 5-7, 2014, Würzburg, Germany.
K. Tran, J. Maga, F. Haemmerling, B. Youn, S. Gu, D. Krawitz, and K. Antonsen
Strategy for Implementing Automated High Throughput Process Development for Purification of a Lysosomal Enzyme, 2nd International Conference on High-Throughput Process Development, June 4-7, 2012, Avignon, France.
P. Diederich, F. Hämmerling, J. Hubbuch
High Throughput Screening of Aqueous Two-Phase Systems for the Purification of Hen’s Egg White Protein Avidin, GVC/DECHEMA „Bioverfahrenstechnik an Grenzflächen”, May 30-June 1, 2011, Potsdam, Germany.