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Dr.-Ing. Sigrid Hansen

Postdoc
Raum: R. 119
Tel.: +49 721 608 47527
sigrid hansenBuf4∂kit edu

Engler-Bunte-Ring 3
Gebäude 40.12
76131 Karlsruhe


Lebenslauf und Publikationen

 

Wissenschaftlicher CV

06/2008 - jetzt

Doktorandin am Institut für Bio- und Lebensmitteltechnik

Karlsruher Institut für Technologie (KIT)

05/2008

Diplom Ingenieurin Biotechnologie

06/2007 – 05/2008

Diplomarbeit: „Aufreinigung von monoklonalen Antikörpern – Entwicklung von Hochdurchsatzverfahren“

Forschungszentrum Jülich in Zusammenarbeit mit der Firma Genentech

05/2005 - 12/2006

Studentische Hilfskraft: „Metabolische Stoffflussanalyse des Sterolmetabolismus in Saccharomyces serevisiae“

Institut für Bioverfahrenstechnik, TU Berlin

06/2004 – 12/2004

Studienarbeit: „Wachstum von Dehalococcoides Species Stamm CBDB1 mit 2,3-Dichlorphenol als Elektronenakzeptor"

Institut für Technische Biochemie, TU Berlin


Forschungsbereich

 

Entwicklung und Etablierung von Hochdurchsatz-Proteinanalytik für Applikationen im Bereich der Bioproduktaufarbeitung

 

Publikationen

 

Poster

 

Sigrid K. Hansen, Jürgen Hubbuch
Evaluation of chromatographic separations for selective protein quantification based on multivariate calibration
ISPPP (International Symposion on Separation of Proteins, Peptides and Polynucleotides), September 2010, Bologna

Sigrid K. Hansen, Arne Staby, Erik Skibsted, Jürgen Hubbuch
Exploring the practical application of protein spectra for selective protein quantification
GVC/Dechema-Tagung „Bioverfahrenstechnik an Grenzflächen“, Mai 2011, Potsdam

Sigrid K. Hansen, Erik Skibsted, Arne Staby, Jürgen Hubbuch
Inline Analytics for Preparative Chromatographic Separations Based on Multivariate Calibration of Protein Spectra
European Congress of Applied Biotechnology, September 2011, Berlin (Posterpreis)

Paper

 

Adrian, L.; Hansen, S. K.; Fung, J. M.; Gorisch, H.; Zinder, S. H.
Growth of Dehalococcoides Strains with Chlorophenols as Electron Acceptors
Environmental Science & Technology, 41 (
2007) 2318-2323

Sigrid K. Hansen, Erik Skibsted, Arne Staby, Jürgen Hubbuch
Label-free methodology for selective protein quantification by means of absorption measurements
Biotechnology and Bioengineering, 108 (2011) 2661-2669

Patrick Diederich, Sigrid K. Hansen, Stefan A Oelmeier,  Bianca Stolzenberger, Jürgen Hubbuch
Sub-two minutes method for monoclonal antibody-aggregate quantification using parallel interlaced size exclusion high performance liquid chromatography.
Journal of Chromatography A, 1218 (2011) 9010-9018

A. Osberghaus, K. Drechsel, S. K. Hansen, S.K. Hepbildikler, S. Nath, M. Haindl, E. von Lieres, J. Hubbuch
Model-integrated process development demonstrated on the optimization of a robotic cation exchange step
Chemical Engineering Science,76 (2012)129-139

K. Treier, S. K. Hansen, C. Richter, P. Diederich, J. Hubbuch, P. Lester
High-throughput methods for miniaturization and automation of monoclonal antibody purification processes
BIOTECHNOLOGY PROGRESS, 28 (2012) 723-732

Sigrid K. Hansen, Benjamin Maiser, Jürgen Hubbuch
Rapid quantification of protein-polyethylene glycol conjugates by multivariate evaluation of chromatographic data
Journal of Chromatography A, 1257 (2012) 41-47

Sigrid K. Hansen, Erik Skibsted, Jürgen Hubbuch
Selective High Throughput Protein Quantification Based on UV Absorption Spectra, Biotechnology and Bioengineering
Biotechnology and Bioengineering, 2012, accepted

Florian Dismer, Sigrid K. Hansen, Jürgen Hubbuch
Accurate retention time determination of co-eluting proteins in analytical chromatography by means of spectral data
Biotechnology and Bioengineering, 2012, accepted

Vorträge

 

Workshop zu:
A-Mab: a Case Study in Bioprocess Development
Downstream Days Summer School, 13.-16.09.2011, Wetter a. d. Ruhr

Sigrid K. Hansen, Erik Skibsted, Arne Staby, Jürgen Hubbuch
Selective protein quantification using multivariate calibration - An analytical tool for high-throughput experimenting and inline monitoring of chromatographic separations
International Conference on High-Throughput Process Development, Oktober 2010, Krakau

Sigrid K. Hansen, E. Skibsted, A. Staby, J. Hubbuch
Fast Analytical Tools Applicable for Protein Purification Process Development and Monitoring
ACS National Meeting 2012, San Diego

Sigrid K. Hansen, F. Dismer, S. Oelmeier, P. Diederich, E. Skibsted, A. Staby, J. Hubbuch
Fast Protein Analytics – Multivariate Calibration Minimizes the Tradeoff between Speed and Information
Recovery of Biological Products 2012, Stowe